What is the CAS number for ISOGINKGETIN?

The CAS number of ISOGINKGETIN is 548-19-6.

What is ISOGINKGETIN (548-19-6) used for?

Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 µM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 µM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 µM. Isoginkgetin (5-20 µM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.InChI:InChI=1/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3

What is the CAS number for ISOGINKGETIN?

The CAS number of ISOGINKGETIN is 548-19-6.

What is ISOGINKGETIN (548-19-6) used for?

Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing. Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; ) and LPS by approximately 87 and 90%, respectively. It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; ) and the calcium ionophore A23187 by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM. Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.InChI:InChI=1/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3

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ISOGINKGETIN

CAS No.: 548-19-6
Purity: 99%

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What is the ISOGINKGETIN ?

ISOGINKGETIN is , while it's Molecular Formula is C32H22 O10. Used in Pharmaceutical Industry:
Isoginkgetin is used as a potential therapeutic agent for various applications due to its inhibitory effects on pre-mRNA splicing, cell growth arrest, lymphocyte proliferation suppression, and MMP-9 reduction.
Used in Research Applications:
Isoginkgetin is used as a research tool for studying the effects of pre-mRNA splicing inhibition on cell growth and function, as well as its potential role in modulating immune responses and MMP-9 activity.

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