Allicin

  • CAS No.: 539-86-6
  • Purity: 99%
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1.What is the Allicin ?

An antibacterial substance extracted from garlic (allium).

Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 μM, respectively. It shows antiparasitic activity against P. falciparum (IC50 = 5.2 μM) and T. b. brucei (IC50 = 13.8 μM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 μM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines. It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.

2.What is the CAS number for Allicin ?

The CAS number of Allicin is 539-86-6.

3.What are another words for Allicin ?

Synonyms?for?Allicin 539-86-6:2-Propene-1-sulfinothioicacid, S-2-propen-1-yl ester;2-Propene-1-sulfinicacid, thio-, S-allyl ester (7CI,8CI);2-Propene-1-sulfinothioic acid,S-2-propenyl ester (9CI);Alliosan;Diallylthiosulfinate;Thio-2-propene-1-sulfinic acid S-allyl ester;

4.What is Allicin (539-86-6) used for?

Allicin is naturally formed by the action of the enzyme allicinase on alliin when the tissue of the garlic bulb is disrupted. Allicin shows antibacterial activity.

This product conforms to the national standards for chemical drugs. The current clinical used forms are allicin injection, garlic instant kelp capsule, etc. It is used clinically mainly for anti-pathogenic microbial infection, anti-tumor, and anti-dilation of blood vessels. It could also be used for the treatment of periodontitis and ulcerative colitis.

InChI:InChI=1/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2

Relevant articles related to Allicin:

Article

Source

Analysis of responses of allicin, a compound from garlic, in the pulmonary vascular bed of the cat and in the rat

Kaye, Alan D.,Nossaman, Bobby D.,Ibrahim, Ikhlass N.,Feng, Chang J.,McNamara, Dennis B.,et al.

, p. 21 - 26 (1995)

Therapeutic effect and mechanism study of L-cysteine derivative 5P39 on LPS-induced acute lung injury in mice

He, Yanting,Zhao, Yalei,Feng, Yuchen,Ren, Anqi,Zhang, Yunyi,Wang, Yang,Li, Hong

, (2020)

The beneficial effects of Allicin in chronic kidney disease are comparable to Losartan

García Trejo, Ehécatl Miguel ángel,Buendía, Abraham Said Arellano,Reyes, Omegar Sánchez,Arroyo, Fernando Enrique García,García, Raúl Arguello,Mendoza, María Lilia Loredo,Tapia, Edilia,Lozada, Laura Gabriela Sánchez,Alonso, Horacio Osorio

, (2017)

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