phosphoribosylamine

  • CAS No.: 14050-66-9
  • Purity: 99%
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Cost-effective customized wholesale phosphoribosylamine 14050-66-9 We provide high quality phosphoribosylamine (CAS 14050-66-9), at a very affordable prices to our customers.

1.What is the phosphoribosylamine ?

Phosphoribosylamine, also known as 5-phosphoribosyl-1-amine, is a vital intermediate in the biosynthesis of purine and pyrimidine nucleotides. It is synthesized through the condensation of 5-phosphoribosyl-1-pyrophosphate (PRPP) and ammonia, catalyzed by the enzyme glutamine-PRPP amidotransferase. Phosphoribosylamine plays a crucial role in the formation of nucleotide bases adenine and guanine, which are essential for the synthesis of DNA and RNA. These bases are vital for cellular processes such as gene expression, protein synthesis, and energy transfer. As a key intermediate in the regulation of nucleotide biosynthesis and cellular metabolism, phosphoribosylamine is indispensable for maintaining cellular function and integrity.

Used in Pharmaceutical Industry:
Phosphoribosylamine is used as a precursor in the synthesis of nucleotide bases adenine and guanine for the development of drugs targeting various diseases. Its role in the biosynthesis of DNA and RNA makes it a potential target for therapeutic interventions in conditions related to genetic disorders, cancer, and viral infections.
Used in Biochemical Research:
Phosphoribosylamine is utilized as a research tool in biochemical studies to investigate the mechanisms of nucleotide biosynthesis, cellular metabolism, and the regulation of gene expression. It helps researchers understand the molecular pathways involved in various biological processes and develop targeted therapies for diseases.
Used in Diagnostic Applications:
Phosphoribosylamine can be employed as a biomarker in diagnostic assays to monitor the activity of enzymes involved in nucleotide biosynthesis. Abnormal levels of phosphoribosylamine may indicate deficiencies or imbalances in cellular metabolism, providing valuable information for the diagnosis and management of metabolic disorders and genetic diseases.
Used in Nutritional Supplements:
Phosphoribosylamine may be used as a nutritional supplement to support the synthesis of nucleotides and maintain optimal cellular function. It can be incorporated into dietary supplements or functional foods to promote overall health and well-being.

2.What is the CAS number for phosphoribosylamine ?

The CAS number of phosphoribosylamine is 14050-66-9.

More information of phosphoribosylamine 14050-66-9 are:

CAS?Number

14050-66-9

Density

1.791g/cm3

Boiling Point

543°Cat760mmHg

Flash Point

282.2°C

Vapor Pressure

4.69E-14mmHg at 25°C

Refractive Index

1.59

PSA

152.28000

LogP

-1.79860

3.What is the molecular formula of phosphoribosylamine ?

The chemical formula of?phosphoribosylamine is C5H12 N O7 P which containing 5 Carbon atoms,12 Hydrogen atoms,1 Nitrogen atoms,7 Oxygen atoms and 1 Phosphorus atoms,and the molecular weight, and the molecular weight of phosphoribosylamine is 273.09

4.What is phosphoribosylamine(14050-66-9)used for?

Phosphoribosylamine, also known as 5-phosphoribosyl-1-amine, is a vital intermediate in the biosynthesis of purine and pyrimidine nucleotides. It is synthesized through the condensation of 5-phosphoribosyl-1-pyrophosphate (PRPP) and ammonia, catalyzed by the enzyme glutamine-PRPP amidotransferase. Phosphoribosylamine plays a crucial role in the formation of nucleotide bases adenine and guanine, which are essential for the synthesis of DNA and RNA. These bases are vital for cellular processes such as gene expression, protein synthesis, and energy transfer. As a key intermediate in the regulation of nucleotide biosynthesis and cellular metabolism, phosphoribosylamine is indispensable for maintaining cellular function and integrity.

InChI:InChI=1/C5H12NO7P/c6-5-4(8)3(7)2(13-5)1-12-14(9,10)11/h2-5,7-8H,1,6H2,(H2,9,10,11)/t2-,3-,4-,5?/m1/s1

Relevant articles related to phosphoribosylamine:

Article

Source

An efficient chemical and enzymic synthesis of nicotinamide adenine dinucleotide (NAD+).

Walt, David R.,Findeis, Mark A.,Rios-Mercadillo, Victor M.,Auge, Jacques,Whitesides, George M.

, p. 234 - 239 (2007/10/02)

5.Cost-effective customized wholesale phosphoribosylamine 14050-66-9

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