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Factory supply rotundine 483-14-7 with sufficient production capacity
- Molecular Formula: C21H25NO4
- Molecular Weight: 355.434
- Appearance/Colour: Off-white solid
- Melting Point: 141-143 °C
- Boiling Point: 482.9 °C at 760 mmHg
- PKA: 6.53±0.20(Predicted)
- Flash Point: 138.7 °C
- PSA： 40.16000
- Density: 1.23 g/cm3
- LogP: 3.31440
483-14-7 Relevant articles
Total Synthesis of (-)-Canadine, (-)-Rotundine, (-)-Sinactine, and (-)-Xylopinine Using a Last-Step Enantioselective Ir-Catalyzed Hydrogenation
Chen, Fener,Chen, Wenchang,Chen, Yu,Jiang, Meifen,Li, Weijian,Tang, Pei,Yang, Zhi
, p. 8143 - 8153 (2021/06/28)
A concise asymmetric total synthesis of ...
Method for synthesizing tetrahydroberberine and derivatives thereof
-
Paragraph 0094-0099, (2021/07/08)
The invention provides a method for synt...
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile
Sun, Haifeng,Zhu, Liyuan,Yang, Huicui,Qian, Wangke,Guo, Lin,Zhou, Shengbin,Gao, Bo,Li, Zeng,Zhou, Yu,Jiang, Hualiang,Chen, Kaixian,Zhen, Xuechu,Liu, Hong
, p. 856 - 868 (2013/03/13)
An effective and rapid method for the mi...
Asymmetric synthesis of (S)-(-)-tetrahydropalmatine and (S)-(-)-canadine via a sulfinyl-directed Pictet-Spengler cyclization
Mastranzo, Virginia M.,Olivares Romero, José Luis,Yuste, Francisco,Ortiz, Benjamín,Sánchez-Obregón, Rubén,García Ruano, José L.
experimental part, p. 1266 - 1271 (2012/02/15)
(S)-(-)-Tetrahydropalmatine 2 and (S)-(-...
483-14-7 Process route
-
![2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline](/upload/2026/10/10eedbf8589f44c29d3f3b9e2e155647_ad25b8fd-60fd-45e3-b718-c46b84fd7fd1.png)
-
26067-60-7
2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline
-
-
483-14-7,2934-97-6,3520-14-7,10097-84-4,84-38-8
tetrahydropalmatine
| Conditions | Yield |
|---|---|
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R,R)-1,1'-bis{(R)-4,5-dihydro-3H-dinaphtho[1,2-c:2',1'-e]-phosphepino}ferrocene; hydrogen; acetic acid; potassium bromide;
In
dichloromethane;
at 25 ℃;
for 72h;
under 60804.1 Torr;
enantioselective reaction;
Inert atmosphere;
|
95%
|
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; 1,1'-bis{(S)-4,5-dihydro-3H-binaphtho[1,2-C:2',1'-e]phosphino}ferrocene; acetic acid; potassium bromide;
In
dichloromethane;
at 20 ℃;
for 100h;
under 45603.1 Torr;
Autoclave;
|
94%
|
-
-
50-00-0,30525-89-4,61233-19-0
formaldehyd
-
![(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline](/upload/2026/10/bc5a4d1628b344c3a55976915c5e4825_cdb5907a-4d5e-441a-9b57-2553c493ae4d.png)
-
1356336-76-9
(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
-
-
483-14-7,2934-97-6,3520-14-7,10097-84-4,84-38-8
tetrahydropalmatine
| Conditions | Yield |
|---|---|
|
formaldehyd; (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;
With
trifluoroacetic acid;
In
toluene;
at 140 ℃;
for 0.5h;
Microwave irradiation;
With
sodium hydroxide;
In
water;
pH=8;
|
56%
|
483-14-7 Upstream products
-
186581-53-3
diazomethane
-
6487-33-8
(-)-isocorypalmine
-
6018-39-9
corypalmine
-
2934-97-6
(+/-)-tetrahydropalmatine
483-14-7 Downstream products
-
6487-33-8
(-)-isocorypalmine
-
605-34-5
(S)-scoulerine
-
2506-20-9
2,3,9,10-tetramethoxy-13aα-berbine; hydrochloride
-
77519-57-4
(S)-(-)-8-oxoxylopinine
