.png)
Chinese factory supply BENZP-DINITRIDE-THIO-KETONE 4547-02-8 in stock with high standard
- Molecular Formula:C15H11ClN2S
- Molecular Weight:286.785
- Appearance/Colour:light yellow crystal
- Vapor Pressure:6.79E-07mmHg at 25°C
- Melting Point:248-250 °C
- Refractive Index:1.684
- Boiling Point:408.9 °C at 760 mmHg
- PKA:9.72±0.40(Predicted)
- Flash Point:201.1 °C
- PSA：56.48000
- Density:1.32 g/cm3
- LogP:3.50390
BENZP-DINITRIDE-THIO-KETONE(Cas 4547-02-8) Usage
InChI:InChI=1/C15H11ClN2S/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
4547-02-8 Relevant articles
Simple synthetic process of quazepam intermediate
-
Paragraph 0019-0021, (2019/05/08)
The invention discloses a simple synthet...
An alprazolam intermediate benzodiazepine preparation process of thione
-
Paragraph 0019; 0025; 0026; 0027; 0028, (2016/10/10)
The invention relates to a preparation m...
Pyrazolobenzodiazepines: Part I. Synthesis and SAR of a potent class of kinase inhibitors
Liu, Jin-Jun,Daniewski, Irena,Ding, Qingjie,Higgins, Brian,Ju, Grace,Kolinsky, Kenneth,Konzelmann, Fred,Lukacs, Christine,Pizzolato, Giacomo,Rossman, Pamela,Swain, Amy,Thakkar, Kshitij,Wei, Chung-Chen,Miklowski, Dorota,Yang, Hong,Yin, Xuefeng,Wovkulich, Peter M.
scheme or table, p. 5984 - 5987 (2010/10/21)
A novel series of pyrazolobenzodiazepine...
Reactions of 1,4-benzodiazepinic N-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam
Del Pozo, Carlos,Macias, Alberto,Alonso, Eduardo,Gonzalez, Javier
, p. 2697 - 2703 (2007/10/03)
Reaction of 1,4-benzodiazepinic N-nitros...
4547-02-8 Process route
-
-
2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
-
-
4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione
| Conditions | Yield |
|---|---|
|
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one;
With
aluminum (III) chloride; chlorine;
In
dichloromethane;
at 10 - 20 ℃;
With
sodiumsulfide nonahydrate; tetrabutylammomium bromide; dihydrogen peroxide;
for 2h;
Reflux;
|
78.7% |
-
-
1088-11-5
desmethyldiazepam
-
-
4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione
| Conditions | Yield |
|---|---|
|
With
n-butyllithium; tetraphosphorus decasulfide;
In
tetrahydrofuran; hexane;
for 16h;
Heating;
|
87% |
|
With
tetraphosphorus decasulfide;
In
pyridine;
Heating;
1.) 30 min. reflux, 2.) 1 h;
|
67% |
|
With
tetraphosphorus decasulfide; sodium hydrogencarbonate;
In
acetonitrile;
for 24h;
Heating;
|
|
|
With
Lawessons reagent;
In
1,2-dimethoxyethane;
at 75 ℃;
|
|
|
With
tetraphosphorus decasulfide; triethylamine;
In
toluene;
at 75 ℃;
for 8h;
Solvent;
Temperature;
Inert atmosphere;
|
175 g |
4547-02-8 Upstream products
-
1088-11-5
desmethyldiazepam
-
59318-11-5
di-morpholin-4-yl-phosphinic acid 7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl ester
-
719-59-5
5-chloro-2-aminobenzophenone
-
2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
4547-02-8 Downstream products
-
77176-00-2
N-Benzyl-N-(7-chlor-5-phenyl-3H-1,4-benzodiazepin-2-yl)-hydroxylamin
-
117267-50-2
8-chloro-1-(5-methyl-4-imidazolyl)-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine
-
76879-39-5
C21H16N2O6
-
57963-16-3
N-<<2-<<7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide
